MyBioSource.com's Mouse Anti-Hace 1 Antibody is a Mouse monoclonal antibody. It reacts with Human. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Flow Cytometry, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Anti-Human HACE 1 monoclonal antibody binds HACE 1 (HECT domain and ankyrin repeat containing), an E3 ubiquitin protein ligase 1 that has ubiquitin ligase activity. HACE 1 was found to be a tumor suppressor which is down-regulated in human Wilm's tumor. HACE1 is frequently downregulated in human tumors and maps to a region of chromosome 6q21 implicated in multiple human cancers. Genetic inactivation of HACE1 results in the development of spontaneous, late-onset cancer. A second hit from either environmental triggers or genetic heterozygosity of another tumor suppressor, p53, markedly increases tumor incidence in a HACE 1-deficient